The Substance
“Have you ever dreamt of a better version of yourself?”
Where to watch The Substance in Italy
The Substance is streaming on Paramount Plus, iWonder Full Amazon channel and Paramount+ Amazon Channel in Italy, and available to rent or buy on Apple TV Store, Rakuten TV, Amazon Video and CHILI. Availability checked 14 June 2026.
About The Substance
The Substance is a 2024 movie in the Horror, Science Fiction and Thriller genres, directed by Coralie Fargeat, starring Demi Moore, Margaret Qualley and Dennis Quaid. It has a runtime of 2 hours 21 minutes. It holds an average rating of 7.1/10 from 6,056 viewers. Below you can see where to watch The Substance in Italy — across streaming, rental and purchase options — along with the full cast, trailer and viewer reviews.
The Substance trailer
Overview
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Top cast
Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
Edward Hamilton-Clark
Fred
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jonathon Carley
Assistant Casting Director
Jiselle Henderkott
Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
TV Host
Vincent Colombe
Man in Suit #1 - Harvey's Office
Billy Bentley
Man in Suit #2
Lennard Ridsdale
Man in Suit #3
Jordan Ford Silver
Assistant Director - Pump It Up Show
Oscar Salem
2nd Assistant Director - Pump It Up Show
Viviane Bossina
Sue's Assistant
Themes & keywords
Frequently asked questions
Where can I watch The Substance in Italy?+
In Italy, you can stream The Substance on Paramount Plus, iWonder Full Amazon channel and Paramount+ Amazon Channel. It's also available to rent or buy on Apple TV Store, Rakuten TV, Amazon Video and CHILI.
Is The Substance on Netflix?+
The Substance is not on Netflix in Italy right now, but you can stream it on Paramount Plus, iWonder Full Amazon channel and Paramount+ Amazon Channel.
How long is The Substance?+
The Substance has a runtime of 2 hours 21 minutes (141 minutes).
Who stars in The Substance?+
The Substance stars Demi Moore, Margaret Qualley, Dennis Quaid, Edward Hamilton-Clark and Gore Abrams.
When did The Substance come out?+
The Substance is a 2024 movie directed by Coralie Fargeat.
What genre is The Substance?+
The Substance is Horror, Science Fiction and Thriller film.
Who directed The Substance?+
The Substance was directed by Coralie Fargeat.
User reviews
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